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This comprehensive review explores the potential synergistic impact of pathway analysis, computational approaches, and molecular genetic manipulation strategies on improving TAG production in microalgae.
The use of systems-level studies makes it possible to comprehensively understand the impact of pathway engineering within the context of the entire host metabolism, to diagnose stresses due to product synthesis, and provides the rationale to cost-effectively engineer optimal industrial microorganisms.
Developmental timing alters the functional impact of pathway activation on cortical neuronal precursor cells (Hirabayashi and Gotoh, 2005).
We proposed this study to determine the impact of pathway antibiotics on patient survival, hospital length of stay (LOS), and total hospital cost.
Investigations of the impact of pathway structure on nucleotide divergence in the insulin/Tor-signaling pathway in Drosophila and vertebrates consistently reveal that they show the reverse-polarity situation, with downstream proteins tending to evolve more slowly than upstream proteins (Alvarez-Ponce et al. 2009, 2010).
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The DIA analysis provides an evaluation of the impact of pathways within sub-categories of KEGG (Additional File 2: Sheet 'DIA KEGG'DIA
Examining the employment impact of Pathways, one report [ 33] found no significant difference by gender, whereas the follow up [ 34] found a larger positive effect for women and for those with dependent children.
To examine the impact of specific pathway modules on differential ERK activities, we divided the entire EGFR pathway into three modules and only perturbed parameters that were involved in a particular subsystem.
Here, we studied the detection of extracellular glucose concentrations in vivo by invalidating the transduction pathway downstream from the transporter-detector GLUT2 and measured the physiological impact of this pathway.
These analyses assess the sensitivity of the models to the parameter estimates elicited from clinicians and Delphi panel members, and estimate the direct impact of treatment pathway characteristics on the cost-effectiveness of BUCCOLAM across countries.
By modifications of the gene cluster composition production profiles were directed towards target compounds and valuable information about the function and impact of selected pathway proteins on COR biosynthesis were obtained.
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