Sentence examples for impact of mutant from inspiring English sources

Petitjean, A. et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

The capacity to identify linked mutations could be important for understanding the persistence [20] and clinical impact of mutant variants.

Two summary measures are used to compare the effectiveness of alternative strategies: (a) Emergence of resistance is measured using the cumulative proportion of all strains resistant to one or both drugs, as a function of time (b) The impact of mutant strains on outbreak dynamics is assessed by the time to reach half of the final attack rate (tmed).

Considering the positive association of SYN2 mutations with ASD, we further analyzed the impact of mutant SYN2 in vitro.

When TRAIL was studied as a classical activator of the extrinsic apoptosis signaling cascade, the impact of mutant p53 was completely different.

We used high throughput screening with MDR-related and non-related antitumour compounds in order to evaluate the impact of mutant (mut) β-catenin on in vitro drug sensitivity.

Hence, we conclude that our LRET assay faithfully monitors the impact of mutants on PPInts.

With a firm understanding of immunoassay mutant detection, the diagnostician can select the appropriate HBsAg screening algorithm to minimize the impact of mutants in sentinel screening programs.

Nishant K. T. (IISER Thiruvananthapuram, India) described the impact of mutants of Msh4, one of these SC-associated proteins, on obligate crossover formation and chromosome segregation.

Perhaps of greatest interest with regard to the impact of mutants on catalysis, the fluorescent data with V260A implicate a temperature-dependent communication from the cofactor binding domain to the fluorescence properties at Trp87 on the substrate domain.

In addition, a small number of knock-in mouse strains for FAD PSEN1 mutations have been created, in which the mutant alleles are expressed under control of the endogenous mouse PSEN1 promoter, and few studies have investigated the impact of the mutant alleles on Aβ production, processing of other γ-secretase substrates, and γ-secretase-independent functions of PSEN [ 66- 69].