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To minimize the impact of maturation in learning and memory or practice effects on performance a three-week interval between the puzzle and book form was used [ 13, 33].
In the youngest age group (< 2 years), it is also necessary to take into account the impact of maturation of the organs and/or enzymes involved in elimination of the drug under study.
In contrast, later childhood adversities showed a main and more enduring-type effect on depressive symptoms at age 17 for adolescent boys, consistent perhaps with the impact of maturation on cognition as suggested above.
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By considering the aforementioned ontological changes to anatomy, physiology, and biochemistry, pediatric PBPK models capable of assessing the impact of growth and maturation on drug PK can be developed.
Thus, we conclude that temporary depletion of harmonin from Müller glia during retinal development has a lasting, adverse impact on maturation of cone ribbon synapses.
These data demonstrate the impact of sexual maturation on body composition, and the importance of assessing sexual maturation in adolescents.
Our results highlight the use of task potency for modelling developmental trajectories and the impact of differential maturation across tasks.
The effects of T-cell subclonal competition, within each clone, on disease progression and level of autoantibody are investigated to determine the impact of avidity maturation on beta-cell destruction.
Particularly in the context of fisheries-induced evolution, the impact of advanced maturation on population productivity might be underestimated if the increase in natural mortality owing to the survival cost of reproduction is excluded (see Andersen and Brander 2009; Kinnison et al. 2009).
There was no impact of timing of maturation on two common measures of regional fat distribution.
To study the impact of in vitro maturation (IVM) on embryonal development with the use of time-lapse imaging.
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