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The phenotype of acute exacerbation leading to death in ICU and the impact of exacerbation frequency is not well studied.
1 2 8 9 Several epidemiological studies support this by demonstrating an impact of exacerbation history on mortality in patients admitted with AECOPD.
In addition to safety and efficacy outcomes, data on risk factors and the impact of exacerbation on daily life were collected.
This finding reinforces the impact of exacerbation in clinical outcomes; exacerbations of COPD indicate clinical instability and progression of the disease and are associated with increased morbidity, deterioration of comorbidities, and reduced health status [ 12].
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7 The impact of exacerbation-associated hyperglycaemia on late mortality has not been investigated but it is known that diabetes is associated with high late mortality after COPD exacerbation.
There is growing interest in the impact of exacerbations on mortality and morbidity in COPD.
In the present study, the longitudinal impact of exacerbations on thoracic vertebral BMD was explored using chest CT scan data.
The impact of exacerbations requiring hospital admission upon health status is particularly severe, affecting mobility and self-care [ 12, 13].
Data on disease characteristics, risk factors, and the impact of exacerbations on daily life were collected from patients before initiation of moxifloxacin treatment.
Yet it is not clear whether instruments such as the EQ-5D or the SF-12 are suitable to measure the impact of exacerbations on HrQoL.
To the best of our knowledge, this is the first longitudinal study that investigated the impact of exacerbations on comorbidity in COPD patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com