These challenges include ensuring proper representation of a community [ 32], forecasting long-term impacts of basic research [ 33, 34], and threats to internal validity, specifically concerns for decreased randomization and contamination [ 35].
Further translation from 'bedside to bench' of the GCP standards can enhance the information and knowledge to be gained from experimental research, will help addressing the 3 R's of animal studies, and will increase the overall impact and contributions of basic research.
The impact of this sort of basic research is often ultimately greater than research close to application, but it's hard for some people to see the connection to a translational outcome.
The development of a technology to generate iPSCs from differentiated somatic cells by the transduction of a set of transcription factors, OSKM, made a significant impact in the field of basic research for regenerative medicine, in light of their potential use as a cell source for transplantation therapy for various kinds of incurable diseases.
Therefore, elucidating the signaling pathways controlled by Psn remains an important area of basic research that could impact future treatments of AD.
This impact on public health explains the ongoing development of basic research (using genetics, imaging, biomarkers, etc).
This core is intended to facilitate clinical investigations either patient-oriented or population-based research that would enhance translation of basic research findings into practical impacts for patients and communities.
Kan et al. discuss the health impact of outdoor pollution in China, and Wang and Chen discuss the funding of basic research in China.
A key argument for government funding of basic research — research driven by curiosity, with no immediate impact in sight — is that past discoveries have eventually been harnessed and improved lives.
However, there is a lack of basic research in understanding how oxidative stress can have an impact on reproduction.
