The prognostic impact of chromosomal abnormalities is now recognized, and the detection of specific abnormal cytogenetics is beginning to influence therapeutic decisions.
In addition, these sequences allow the impact of morphological abnormalities on regional and global function to be assessed.
The impact of metabolic abnormalities on obesity-related co-morbidities has undergone intense scrutiny over the past decades.
Sleep alterations are known to have deleterious consequences in healthy subjects, but the paucity of data in the literature [4 7] makes it difficult to determine the impact of sleep abnormalities in ICU patients.
The impact of structural abnormalities on the clinical performance of patients with TBM is unknown.
Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial.
However, the biological impact of these abnormalities in renal disease is largely unknown and should be clarified by future studies.
Given the substantial impact of neurodevelopmental abnormalities in society and the likely impact of environmental aetiologies, prevention of pesticide exposure appears to be an obvious public health priority.
In the light of major impact of renal abnormalities on CVD, these programmes are urgently warranted and should be implemented according to single-nation characteristics.
Although the association between consumptive coagulopathy and progressive hemorrhagic injuries and clinical outcome has been reported [ 6– 11], the impact of hemocoagulative abnormalities on PTCI was seldom addressed.
