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The hypoxic, acidified, and nutrient-deprived environment causes metabolic stress to neighboring non-malignant cells and acts as a barrier shielding the tumor from any impact mediated by tumor-specific T effector cells residing or recruited in the tumor microenvironment (Fig. 2).
Such a double signaling impact mediated by the two components of the heterotrimeric G protein complex leads to initiation of two cellular programs - apoptosis and epithelial-mesenchymal transition - which cumulatively result in wing expansion and solidification (Fig. 7), producing the adult flight organ.
For instance, the technique cannot always strictly differentiate between the direct impact of a therapy on the affective-motivational aspect of pain processing and the "secondary" impact, mediated via the sensory-discriminative pain pathway.
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According to a mediating variable framework, interventions impact mediating variables, which then act on behaviors and other outcomes [ 51].
The results supported the first hypothesis, which was explained by land-use impacts mediated by soil properties.
Commonly, conformity with existing applicable environmental regulations such as the Clean Air Act (1990) serves as a proxy for the health and safety performance of a project, and EIA rarely extends to consider health impacts mediated via changes in the built environment, social determinants, or economic impacts (Davies and Sadler 1997).
Changes in fish behavior have received relatively little attention, despite significant evidence of behavioral change driven by human impacts mediating function and processes in terrestrial ecosystems, and emerging evidence that the same is true in marine systems even within marine reserves.
Gradually making the reference-group smaller primarily affected perceived impact, and impact completely mediated the PDE.
To examine the relationships between study quality, author prestige, journal impact factors, and citation rates of trials and to examine whether journal impact factors mediated the relationships between study quality and author prestige on citation rates.
So, the themes here have to do with "social impact," probably mediated by social media, while watching out for compelling scams.
Most of its impact was mediated through people's susceptibility to psychological distress and physical health problems.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com