There are many factors contributing to the regulation of transcription, having varying impact in the difference in expression level and the time scale over which the expression level may change, either within a cell or over a course of cell divisions.
The impact of changes in the expression of zinc transporters on other actions of zinc in islets (most notably regulation of β-cell mass and glucagon secretion) remains to be settled [7].
AZA exposure experiments confirmed the impact of methylation in the expression of this gene by specifically restoring their transcript and protein expression in methylated bladder cancer cells.
In contrast, leptin had no impact on the expression of PPARα in liver, skeletal muscle or adipose tissue.
Furthermore, we found evidence for the contribution of xenobiotic exposure to environmental carcinogenesis at the molecular level in terms of impact on the expression of genes related to metabolism, stress response, signaling pathways, and tumorigenesis.
High content analysis showed that 4e and 4m induced a dose-dependent increase of dimethylated Lys4 of histone H3 and had no impact on the expression of LSD1 in MGC-803 cells.
This, in turn, has an impact on the expression of IFN-β through its binding to their common response element.
Sertad2 is the closest homolog of Sei1, and we wondered whether inactivation of Sei1 had an impact on the expression of Sertad2 in MEFs.
Mechanical stimuli have different impact on the expression of PG in tendons [ 2- 6].
Intriguingly, different growth conditions had a strong impact on the expression of CRKs in various mutants.
