Sequence variation in CREs can impact gene expression levels, but also developmental timing and tissue specificity of expression.
Our studies not only unravel a novel mechanism by which G9a function is regulated, but provide fundamental insights by which PTMs of chromatin proteins influence the chromatin environment to impact gene expression.
Synonymous mutations have been shown to impact gene expression, protein folding and fitness, however, direct evidence that they can be positively selected, and so contribute to adaptation, is lacking.
Recent genomic studies have illuminated general principles of chromatin organization and deepened our understanding of how promoter sequence and nucleosome architecture may impact gene expression.
The ability to regulate RNA stability has the potential to impact gene expression on a global scale, but is also critical for fine-tuning cellular responses to specific stimuli as well as eliminating flawed and potentially deleterious transcripts.
Teresa's research focuses on the computational analysis of dynamical properties of biological systems, including spatial, temporal and/or contextual variation, and explores how such variations impact gene expression and affect the network topology, function, and phenotype of the organism.
Here, we discuss recent progress on how cellular metabolism is linked to CD8+ T cell fate decisions and on how metabolic intermediates can impact gene expression via modulation of the epigenome.
Doing so, however, reduces the chances of identifying clinically-useful biomarkers that that will be applicable to all patients or reliably distinguish children with the disease from healthy controls regardless of age, ethnicity, or other variables that might impact gene expression.
Francois Jacob, Jacques Monod and their colleagues used the bacteria Escherichia coli to investigate how environmental conditions impact gene expression and regulation (Jacob and Monod 1961; discussed in Craver and Darden 2013; Morange 1998: Ch. 14; Schaffner 1974a; Weber 2005).
Modifications to diet, environment and lifestyle can impact gene expression.
Gene deletion may impact gene expression through a multitude of effects, depending on its precise function.
