Exact(14)
Drug delivery methods can impact efficacy as much as the nature of the drug itself.
Regulatory T (Treg) cells have been shown in some cases to limit vaccine-specific immune responses and impact efficacy.
The development of antibodies to chimeric rituximab has raised concerns that immunogenicity of anti-CD20 mAbs could impact efficacy, tolerability and risk of IRRs.
To ensure that melphalan dosage adjustment in the obese population did not impact efficacy, the primary outcome was assessed using a noninferiority design, with a predetermined noninferiority margin of 7%.
Moreover, it is still not known whether the degree of TSH elevation would impact efficacy.
Recombinant protein therapeutics can be at a risk of development of an antibody response that can impact efficacy and safety.
Similar(46)
We have an increased understanding of the diversity of early-stage disease and how to better tailor treatments to make them more tolerable without impacting efficacy.
Least-squares regression revealed that both patient compliance variables, percent of doses taken and dosing time variability, significantly impacted efficacy and toxicity.
However, the host antibody immune response directed against their capsid, prevalent in ∼40 70% of the general population, depending on serotype, negatively impacts efficacy.
Consequently, intraneuronal Aβ antibody concentrations may not be sufficient to reduce intracellular Aβ, impacting efficacy.
Because product formulation also impacts efficacy [ 15], broad conclusions regarding the efficacy of other products should be made with caution.
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