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We fully agree with this reviewer and the similar comment from Reviewer #3 that additional assessment of other human cells would enhance the impact and conclusions from our study.
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Our data is now corrected and impacted figures and conclusions have been bolded in the text below so readers can see what has changed.
However, binarisation method and processing choices are subjective and can have a strong impact on results and conclusions.
When designing future clinical studies of amblyopia treatment, issues such as regression to the mean, sample size and trial duration must be considered, since each may impact study results and conclusions.
These different approaches may impact results obtained and conclusions drawn.
However, the same bias applied to providers in all three models, and thus, this should not impact our comparisons and conclusions.
Using different statistical methods this study describes the impact on results and conclusions of analyzing health care costs in a population with diabetes.
We have assumed a linear interpolation of EQ5D scores, but while this is common practice, the small absolute differences in effect size suggest that any variation from this may have had an impact on results and conclusions.
The intention is to expose the differences in approach, understand the capacity and resource issues that may impact, and draw some conclusions with regards to future interventions in Durban.
Findings and Conclusions: Impact: There is no doubt that the beneficiaries perceive a lot of impact from the Sida-supported activities that have been implemented through UNICEF.
The aim of the study is to assess variance components in observer performance studies and the possible impact on study results and conclusions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com