Others are internal to the company: difficulty of monitoring, measuring, and communicating impact; alternative investment opportunities that take priority; long time horizons for profitable payback; and lack of clear funding mechanisms.
Taken together, these results demonstrate that iAs can impact alternative splicing of a subset of genes, critical in disease pathology.
Heart transplantation (HTx) improves the outcome of selected patients but, since it has limited epidemiological impact, alternative therapies have been explored.
Additional studies will be necessary to establish whether regulated re-localization of RBM4, or other types of regulation, impact alternative splicing of ULBP1 or other transcripts.
However, in the absence of genetic perturbation of host HIF-1α, the possibility that hypoxia, CoCl2 or DMOG impact alternative pathways in the parasite that mediate the observed infection phenotype cannot be excluded.
Keurig currently offers no minimal-impact alternatives.
As she put it, "I would like it to diversify the unlimited ski-tourism industry with respectful, low-impact alternatives".
Of course, it would be better for businesses and the environment alike if green travel options were cheaper than their higher-impact alternatives.
Luckily, despite the constraints around physical field trips, teachers today have low-cost, high-impact alternatives at their disposal.
Now making a comeback as a low-impact alternative to running in leisure centres and gyms all over the country.
To meet global demands while limiting associated environmental impacts, alternative techniques to extract resources, including gold, are urgently needed.
