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In T-cell proliferative antigen recall assays, a pertinent measure of immunological responsiveness, PA2024-specific responses were present in the majority of sipuleucel-T-treated subjects with the magnitude of the response sustained through at least week 26.
Respiratory sensitization is an immunological state of the respiratory tract that results from specific adaptive immune responses to antigenic exposure, leading to heightened immunological responsiveness after subsequent exposures to the sensitizing antigen.
However, because we are such an out-bred species, immunological responsiveness to any given vaccine is certain to exhibit a high level of inter-individual variation that will impact upon the efficacy, reversibility and feasibility of the approach.
We conclude that immunological responsiveness to vaccination decreases throughout adult life, and that conventional vaccination strategies designed for children and young adults cannot be uncritically applied in the elderly.
Nevertheless, gender differences in filarial-specific immunological responsiveness have never been seen.
Despite differences in disease arising from the site of patent infection [5], and subtle differences in immunological responsiveness [6], [7], the host disease progression of schistosomiasis is essentially similar for all species.
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Many pathological processes have been proposed to explain the pathogenesis of delayed CV after SAH, including endothelial damage, smooth muscle contraction, changing in vascular responsiveness, and inflammatory and/or immunological response of the vascular wall [ 2].
Genetic susceptibility to IgE-responsiveness is likely to be caused by a pattern of polymorphisms in multiple genes regulating immunological responses [7], but so far only a very few loci have been established consistently and robustly [8], [9].
Or it could even be an immunological response to a foreign body growing inside the mother.
Furthermore, the age difference is unlikely to have contributed to the higher Bmem responsiveness of the younger PCV13 infants, as an older and more matured immune system is more likely to show a higher immunological response [ 7, 30].
Thus, the possibility of PPV23-induced immunological hypo-responsiveness upon re-vaccination has to be considered.
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