Exact(5)
However, the presence of living cells may also create a biological threshold owing to immunological requirements.
This chapter categorizes the immunological requirements of different classes of noninfectious diseases to show the underlying immunological mechanisms that have to be considered in the design of appropriate vaccines.
We therefore used MVA in order to define the immunological requirements for the therapeutic protection of mice from a lethal ECTV infection.
Data obtained from animals vaccinated by the oral route provided several insights about the immunological requirements for protection against Ebola in a mouse model.
MVKD participated in the study design, implemented immunological requirements and reviewed the manuscript.
Similar(55)
In three animal models of diseases with markedly different immunological requirement; Mycobacterium tuberculosis (cell-mediated), Chlamydia trachomatis (cell-mediated/humoral) and malaria (humoral) immunization with CAF01-based vaccines elicited significant protective immunity against challenge.
In three animal disease models with markedly different immunological requirement; Mycobacterium tuberculosis (CMI), Chlamydia trachomatis (CMI/humoral) and blood-stage malaria (humoral), immunization with selected candidate vaccine antigens administered in CAF01 gave rise to significant levels of protection.
Furthermore, CD8 is essential for formation of the immunological synapse, a requirement that cannot be overcome by increasing antigen concentration 40.
Higher maintenance requirements, lower immunological competencies, unfavorable feeding behaviors, and perhaps divergence between the doe breeds for major genes that affect fitness are possible contributors to the poor longevity and lifetime reproductive output of Boer does compared with Kiko and Spanish does observed here.
Human allogeneic stem cell therapy relies on these functional characteristics of haematopoietic stem cells that can be isolated from peripheral blood, bone marrow or cord blood, with the additional requirement that immunological barriers need to be overcome to allow sustained engraftment while minimising risk of graft-versus-host disease developing in the recipient of transplanted stem cells.
It is well proved that the transition from immature DCs to mature DCs is accompanied by morphological changes to be suitable for requirement of immunological function changes of DCs.
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