However, the underlying mechanisms for why decreased expression of IFNAR1 on DCs may promote exacerbation of colitis, whether it be through an impaired ability to induce Tregs or an inability to control proinflammatory cytokine expression, such as IL-17 and IL-13, and whether the level of receptor downregulation we observed has significant immunological effects needs to be investigated further.
Consequently, the analysis of immunological data needs the use of specialized computational tools.
This potential immunological relationship needs to be further clarified and if the association is shown to be causative, it may have great implications for the treatment of various cancers and cancer-related depression.
Human allogeneic stem cell therapy relies on these functional characteristics of haematopoietic stem cells that can be isolated from peripheral blood, bone marrow or cord blood, with the additional requirement that immunological barriers need to be overcome to allow sustained engraftment while minimising risk of graft-versus-host disease developing in the recipient of transplanted stem cells.
Larger immunological studies need to be carried out, where several parameters can be measured and correlated for the same individual with follow up tests through different aspects of the disorder (i.e. prodromal state, psychotic episodes etc).
As immunological reagents needed to study T cell responses in ferrets are largely lacking, investigation of influenza vaccine-induced antigen-specific T cell responses will be undertaken in mouse and macaque models and in clinical studies.
Larger immunological studies need to be carried out, where several parameters can be measured and correlated for the same individual with follow up tests throughout the progression of the disorder.
To assess the effect of diethyltoluamide on the fish immune system, more immunological parameters need to be included in the future studies.
Nonetheless, those immunological indexes need to be examined by flow cytometry, which are not routinely performed in every hospital due to its high cost and complexity.
A significant number of immunocompromised patients who develop serious complications related to treatment toxicity and immunological dysregulation need to be transferred to the ICU for advanced supportive care [ 1].
