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In support of a causal relationship, vitamin D beneficially modulates diverse immunologic pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells, and structural cells to dampen excessive inflammatory responses.
These genes come from neuronal, hormonal and immunologic pathways previously associated with migraine.
Selected SNPs were located in genes involved in neuronal, hormonal and immunologic pathways previously associated with migraine.
Our results provide potential biomarkers that identify patients with lSSc, showing a specific subset of lSSc patients with PAH that can be identified through cellular and circulating biomarkers, and suggest pathogenic cellular and immunologic pathways that are upregulated in these patients.
STAT3 is a key regulator of many immunologic pathways.
Fat-free mass, similar to adipose tissue, may play a role in cancer proliferation through various endocrine and immunologic pathways.
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63, 64 These studies suggest that some therapeutic approaches to treatment of patients with MS that target only one immunologic pathway or process may differ in effectiveness relative to those that affect the immune system at multiple levels.
Splenomegaly is related not only to blood congestion as a consequence of increased portal pressure and augmented resistance to splenic vein outflow but also to multiple other histopathologic changes, such as arterial aneurysms [ 22] and concern with endothelin [ 23], and the immunologic pathway from the liver [ 24].
Mechanisms of colorectal cancer (CRC) development can be generally divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota.
Although the pathophysiology of I/R injuries has not been fully elucidated due to complex interactions of inflammatory and immunologic signaling pathways [ 8], it is clear that accumulated free radicals and anaerobic metabolites during ischemia cause the migration of white blood cells and the release of inflammatory factors such as interleukin and free radicals in the reperfusion phase [ 9- 13].
This genetic variation, although not well understood, underscores an immunologic pathogenic pathway.
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