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IRIS is a paradoxical clinical deterioration that occurs even when the immune system begins to improve, while no immunologic improvement occurs in treatment failure [ 10, 13].
Clinical and functional immunologic improvement occurred in the other, who is now 19 months after transplantation.
No functional immunologic improvement occurred in the first infant, who died of pulmonary disease 10 months later.
Recent data suggest that the risk for relapse is rare after 12 months of treatment with a sustained immunologic improvement (CD4 >150/mm) (33 ).
The sustained immunologic improvement in terms of CD4 count at least till 7 years after initiation of therapy, has also been reported from other long term follow-up study in children [ 20].
These facts strongly argue that the T-cell subset was at least partially involved in our patient's enteropathy and was potentially causative, especially considering the failure of dietary exclusion, antibiotics and other therapies in inducing clinical, histologic or immunologic improvement.
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An analysis of efavirenz found equal virologic and immunologic improvements in men and women, but more frequent toxicity-related drug discontinuations in women [ 18].
However the decreasing morbidity and mortality in HAART-treated HIV-1 seropatients pandentheand the following restoration, preservation of immunologic function and improvement in quality of life demand the ongoing use of these drugs.
Age decreased and immunologic characteristics improved in all groups over time in both urban and rural clinics, with greater improvement observed in the rural clinics.
The resultant clinical, immunologic, and virologic improvements in children are similar to those reported with zidovudine in adults.
HIV-infected children receiving treatment in a rural clinic experienced sustained immunologic and virologic improvements.
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