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In addition, Balb/c mice were used which are an inbred strain with an immunologic deficiency.
Subsequently, the resultant monomicrobial bacteremia was likely secondary to bacterial translocation in the setting of immunologic deficiency from an overwhelming preexisting illness (2, 6, 31, 36 ).
Toxicologic effects of PCBs observed in animal studies include carcinogenicity, reproductive impairment, neurodevelopmental anomalies, and immunologic deficiency (Brouwer et al. 1998; Faroon et al. 2001a, 2001b; Seegal 1996).
Lymphocyte transformation assay potentially offers a sensitive indicator for several conditions involving lymphocyte dysfunction due, for instance, to immunologic deficiency [ 8].
Immune related disease genes mainly consist with Autoimmune disease, Immunoproliferative disease, Immunologic deficiency syndromes, hypersensitivity, Graft rejection, Purpura, thrombocytopenia, and Glomerulonephritis.
Chu et al. found that immunosuppression, defined as hematologic or immunologic deficiency or transplantation, was more common in cases of histoplasmosis, when compared with the other endemic mycoses (12 ).
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HIV infection is associated with numerous immunologic deficiencies in nearly every type of immune competent cell, including those that are programmed to inhibit HIV replication [30], [31], [32].
Characterization of the function of Id2 in our murine model at advanced ages is compromised by phenotypic co-morbidities including immunologic deficiencies and lactation defects (Yokota et al., 1999; Mori et al., 2000).
Studies of human patients and mice models have shown that deficiencies in key immunologic components lead to increased susceptibility to the development of cancer [1] [3].
Zinc deficiency is known to impair immunologic functions.
Regulatory T cells play a central role in inducing and maintaining immunologic tolerance and the termination of immune responses, and deficiency or dysfunction of these cells lead to autoimmunity or aggravated pathogen-induced inflammation[8], [9].
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