Following in silico immunization, agents respond to features in their local environment based on low‐level rules informed by the relevant literature as specified in SUPPLEMENTARY FIGURE 1 of Read et al. 40 An example is provided in Figure 2 to illustrate this.
Additionally, the continued presence of antigen specific mouse antibodies 301 days (43 weeks) after the final re-immunization, is potentially an important feature for an immunizing agent and likely to be relevant in terms of practical utility.
(The active immunization of pregnant women against certain viral diseases, such as rubella [German measles], must be avoided, however, because the immunizing agent can cross the placenta and produce severe fetal complications).
One approach to providing these individuals with immunoprophylaxis is to use these vaccines as immunizing agents in healthy adult plasma donors, collect their plasma, and then fractionate it to produce specific hyper-immune gamma immunoglobulin (IGIV) for intravenous passive immunization.
Disrupts immunity or the effectiveness of an immunization against the agent or toxin without clinical or agricultural justification.
Sublingual (SL) immunization against infectious agents or bacterial toxins is not a common route for antigen delivery.
Several other therapeutic approaches involving passive and active immunization, toxin binding agents, lytic bacteriophages, anti-bacterial peptides, phage lytic enzymes and probiotics have been used but they are far from replacing the antibiotic therapy approach [1] [9].
Bile duct injury is also inducible by immunization with different agents.
Application of topical vitamin D analog, calcipotriol, followed by transcutaneous immunization with a protein agent results in induction of iTregs, primarily due to induction of RANKL on keratinocytes which likely modulates DC function to drive iTreg differentiation[ 76].
