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In order to maximize vaccination strategies and achieve herd immunity, coverage rates must remain high (≥ 90%) to reduce circulation of the viruses or bacteria that cause the vaccine-preventable disease.
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This includes high population immunity demonstrated by immunization coverage estimates and supported by seroprevalence studies where available.
The most effective way to stop the circulation of this virus is to increase the immunity of children through increased routine immunization coverage.
The markedly low immunization coverage rates may affect herd immunity, and they would greatly increase those children's susceptibility to vaccine preventable diseases.
In contrast, a serosurvey that measures antibodies produced in response to vaccination provides an objective measure of immunization coverage and the induction of protective immunity.
Routine immunization coverage is critical for children to have adequate immunity against polio and other childhood diseases.
Examining our findings in light of routine immunization coverage data suggests that coverage with TT-containing vaccines remained relatively constant during this 2-year period and supports our claim that PsA-TT boosted tetanus immunity.
Each strategy was tested using different assumptions relating to pre-existing immunity, vaccination coverage, and the timing of the epidemic peak.
Low immunization immunity due to poor OPV coverage in routine immunization was the major risk factor related with VDPV outbreak.
By contrast, when mortality was assessed as the endpoint of interest, an outcome-based strategy was preferred to an attack rate-based strategy for any combination of values for pre-existing immunity and vaccine coverage, with the exception of the assumption of 70 percent immunity to pH1N1 in individuals aged ≥53 combined with a January peak.
However, diphtheria remains a health concern among immigrants, travelers, and those with incomplete immunity and vaccination coverage in many regions.
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