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A potential explanation is that different components of microbial groups or genera share common antigen or molecule structures on their cell wall surface, which are detected by pattern recognition receptors in innate immunity cells and have a profound influences on the immune system (21).
Host defenses against mycobacteria need an immune cellular response (Th1/Th17) activated by cytokines and chemokines produced by innate immunity cells [ 1].
In this context, it is likely to hypothetize that the post vaccination memory mediated by adaptive immunity cells may be important for an effective activity of the innate immune mechanisms.
The acquired immunity cells such as lymphocytes are also affected.
In these patients, several studies showed increased secretion of anti-inflammatory cytokines, e.g., IL-10, and decreased activation of immunity cells, e.g., monocytes [20, 21].
These efforts have focused on targeting extracellular receptors on T and B cells without discerning islet-destructive autoreactive T and B cells from primary innate immunity cells [2], [6].
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In Bhsp65-tolerized group, only 76 (12.86%) of the 579 DEGs were related to immune activity (innate immunity, cell-mediated immunity and humoral immunity).
Nuclear factor-κB (NF-κB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis.
NF-κB regulated genes play important roles in inflammation, immunity, cell growth and cell survival [42], [43], [44], [45].
Further specialization of kinomes in complex organisms like fungi, nematodes or fly, arises in immunity, cell cycle modulation, differentiation, neurogenesis or intercellular communication [47].
The transcription factor NF-κB regulates a broad range of biological processes including innate and adaptive immunity, cell growth, differentiation, apoptosis, and tumorigenesis [1].
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