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Additionally, Akt, JNK, mTOR, and HIF-1α regulate innate immune memory ("trained immunity") by switching from the oxidative phosphorylation to aerobic glycolysis [15, 22, 33].
The model also predicts greatly enhanced immune response upon secondary immunization, consistent with the immune memory phenomenon.
Netea, M. G. et al. Trained immunity: a program of innate immune memory in health and disease.
Netea, M. G. et al. Trained immunity: A program of innate immune memory in health and disease.
This innate immune memory has been termed 'trained immunity'.
A feature of vaccines that confer long-term immunity is their ability to induce immune memory.
We benchmark the resulting model by simulating a classical immunization experiment that reproduces the development of immune memory.
Immune memory is the foundation of the practise of vaccination.
Our results identify immune memory in the brain as an important modifier of neuropathology.
Extended Data Fig. 9 Peripherally applied cytokines induce immune memory in the brain.
Studies of immune memory have primarily focused on effector B cells and T cells.
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