Sentence examples for immune functionality from inspiring English sources
The metabolic cost and functional shift hypotheses regard the architecture underlying immune functionality fundamentally different.
Modern biopharmaceuticals with high potency and target specificity, like antibodies and cytokines need to be tested for their therapeutical doses, their exposition regimens and their immune functionality prior to first-in-man applications.
We postulate that in the future of intensive care, personalized medicine that considers the individual immune functionality will be needed to significantly improve the outcome of affected patients.
The pathophysiology of the complex interactions between metabolism and immune functionality of lymphocytes should be further investigated as it may represent an interesting research field for innovative therapies.
Meanwhile, lactate production by T lymphocytes is one marker of these T cells' bioenergetic status, interconnecting metabolism, and immune functionality (immunometabolism), as it has been shown recently in monocytes [7].
First, beside mHLA-DR measurement, no specific evaluation of septic patients' immune functionality was performed in parallel with CD74 mRNA level.
High lactate concentration in tumor microenvironment might affect immune cells functionality.
However, it should be noted that they do not reflect immune cell functionality as cytokines are mostly pleiotropic, derived from different cells including non-immune cells, may be counteracted by natural inhibitors (e.g., gp130 for IL-6), and have variable clearance rates [4, 6, 11, 12].
Of 14 pathways, 13 were upregulated in improvers and included complement pathway, integrin signaling and extracellular matrix organization suggesting the enrichment in immune system functionality in abatacept improvers at baseline as opposed to the non-improver (Additional file 6B).
Despite the high immunoglobulin G (IgG) levels in children with HIV, measurement of these levels does not appear to be a good marker for humoral immune system functionality as these children often have a decreased response to vaccines [ 22- 24].
