In fact, our data provide first evidence indicating immune distribution of single epitope-specific CD4 T cells in the blood, lymph node, spleen and infected lung after pulmonary M. tuberculosis infection.
In this paper for interpretability we use the "fold range", which is a simple function of that standard deviation (specifically, 103.92σ1), and the fold range is the ratio of the upper to lower quantiles of the middle 95% of each immune distribution (see Supplementary file Text S1 for derivation).
Exosomes are now considered to have multiple functions, including immune regulation, distribution of cell substances, and propagation of prion proteins and retroviruses (Ritchie et al., 2013).
In this review, we examine the evidence for these interactions, including circadian rhythmicity in models of disease and immune challenge, distribution of cytokines and their receptors in the suprachiasmatic nucleus of the hypothalamus, the site of the master circadian pacemaker, and the evidence for endogenous circadian timekeeping in immune cells.
In this study we set out, for the first time, to characterise gene expression and immune cell distribution in the FGT in comparison to the systemic compartment.
The objective of this study was to use a systems approach for investigating the underlying mechanisms by which the deletion of PPAR γ in IEC modulates the severity of experimental IBD, immune cell distribution and global gene expression.
Since most of the HIV-1 positive blood donors and all LN donors enrolled in our study were treatment-naïve at time of sample collection, the effects of anti-retroviral therapy on viral replication, immune cell distribution, activation and function are not expected to influence significantly our results.
In that study, large numbers of CD4+-lymphocytes and of CD1a+-dendritic cells predicted more precisely for NED-survival than axillary lymph node metastasis per se indicating an important functional role of an immune cell distribution shift [ 11].
WT or CD4cre mice were challenged with 2.5% DSS for 7 days to induce experimental IBD and to determine the effect of T cell-specific deletion of PPAR γ on colitis severity, gene expression and immune cell distribution.
The objective of this study was to investigate the mechanisms by which the deletion of PPAR γ in T cells modulates immune cell distribution and colonic gene expression and the severity of experimental IBD.
The objective of this study was to perform a comprehensive time course analysis of the effect of T cell-specific deletion of PPAR γ on the development of experimental IBD by using a systems approach aimed at examining immune cell distribution, global colonic gene expression and gut immunopathology.
