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VDPVs that revert from live oral attenuated vaccines and reacquire characteristics of wild-type polioviruses not only threaten populations with poor immune coverage, but are also a potential source for re-introduction of poliomyelitis into highly immune populations through older individuals with waning immunity.
It is widely assumed that TCR diversity is required, or at least highly desirable, to provide sufficient immune coverage.
Intuitively, stochastic diversification of the repertoire would seem advantageous, maximizing potential immune coverage without prior bias towards certain specificities.
This could occur if individual haplotypes contain non-random combinations of MHC supertypes (i.e. "individual immune repertoires") [ 39] that complement each other to maximise immune coverage against the set of pathogenic pressures encountered in the environment.
Similar(56)
Microvessel densities, pericyte coverage, immune cell infiltration, permeability, hypoxia, and necroses were assessed using Nikon NIS Elements Software by determination of marker‐positive areas or fluorescence intensities.
We thought that we'd become immune to the constant coverage of the Great American Bedbug Infestation of 2010.
By The New Yorker August 25, 2010 We thought that we'd become immune to the constant coverage of the Great American Bedbug Infestation of 2010.
In the late 1980s, most countries have listed measles vaccine to their regular immune plans, and the coverage of the vaccines sees a huge improvement.
This policy was introduced to improve coverage and immune responses [ 9- 13].
In comparison with previous versions, the updated 1.8 K platform (GEO GPL6154) has a substantially improved coverage of immune genes.
While HTS has enabled an unprecedented depth of coverage of immune repertoires (i.e., 10 10 sequencing reads per repertoire), there is still a vast undersampling of biological diversity, especially in human samples [ 9, 65].
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