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While there is no good evidence that a woman's immunity to her partner's tissues is responsible for repeated miscarriage, suggestive evidence indicates that an immune abnormality may occur that interferes with producing the intrauterine growth factors needed for a successful pregnancy.
Since this imbalance is stable over time and independent of several disease parameters, we hypothesize that this is a pre-existing immune abnormality involved in the etiology of AAV.
This excess was not due to a specific infection(s) and may reflect underlying immune abnormality.
The etiology of AITDs includes genetic and environmental factors resulting in immune abnormality and the development of AITDs.
Neither the patient nor her relatives had any other immune abnormality at present or in the past history.
We cannot, however, determine whether the excess of clinically diagnosed infections is a consequence of underlying immune abnormality or indeed, whether the infections are playing a causal role.
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Genes involved in innate and adaptive immunity can contribute to immune abnormalities.
Thalassemic patients present with multiple immune abnormalities that may predispose them to oral Candida, however this has not been investigated.
Exclusion criteria were: relevant comorbidities (renal, liver or heart disease or COPD), previous immune abnormalities (including treatment with corticosteroids), neuromuscular disease, past or recent history of cancer.
This study was designed to assess the status of the gastrointestinal tract and to define the mucosal immune abnormalities in patients with and without symptomatic gut inflammatory disease.
Some of these new agents have been successfully used in other diseases, while others are being specifically designed to interfere with the immune abnormalities seen in SLE.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com