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The found immobilisation effect can reduce the mass of sulphide that corrode metal canisters over repository life times, but the concomitant reduction of ferric iron may be problematic due to the destabilizing effect of ferrous iron on dioctahedral smectites such as montmorillonites.
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Statistical analysis of the measurements showed that immobilisation had a significant effect on specific morphological features of the knee (Table 2).
The mechanism of the effect of immobilisation after insemination is unclear.
Whilst this reversion reduced the number of potential immobilisation sites, the stabilising effect of the K232F and K241N mutations (Ryan and O'Fágáin, in preparation) was evidenced (Table 2; Mutant 4 versus Mutant 2 in free solution).
Separation of small-sized GO sheets together with the BOD immobilisation protocol has detrimental effects on the bioelectrocatalytic reduction of oxygen.
In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation.
Drug treated embryos showed previously reported effects of immobilisation including spinal curvature and joint contracture (not shown) [10], [21].
Narrowing of the intercondylar fossa was one of the strongest effects of immobilisation revealed by the morphometric study (Table 2) and the proportion of proliferating cells was reduced in the cartilage rudiment adjacent to the dorsal aspect of the fossa.
In the current work we compared the effects of immobilisation on the knee and elbow joints in the chick and found that the elbow joint showed similar but no more severe alterations (not shown) highlighting a clear and intriguing difference between avian and mammalian models.
However, this long-standing dogma is unfounded, or at least overplayed, as increasing awareness of the adverse effects of immobilisation become increasingly apparent.
Although this work bears certain similarities to prior work that has evaluated the effects of immobilisation on non-porous nanoparticles [11], confinement of biomolecules in nanoporous materials is fundamentally different.
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