Antisense oligonucleotides (ASOs) show immense potential to control the spread of resistant microbes due to its high specificity of action, little risk to human gene expression, and easy design and synthesis to target any possible gene.
Split the country by state (and union territories) and you get a clear idea of how wide are the internal differences, how immense is the population, and how unequal the spread of wealth and increase in income.
Malignant ascites, which is caused by the intraperitoneal spread of tumor cells, has an immense impact on the quality of life due to its symptoms and frequent recurrence [ 4].
The rapid spread of antibiotic-resistance poses an immense threat to health systems of these countries where adequate antibiotic treatment of infectious diseases is often hampered by financial constraints [ 17- 19].
The spread of these channels, and Digg in particular, is having immense impact not only on our access to the news, but also on the type of reporting that news organizations undertake.
The centre-page spread of the magazine was a medley of cheeky cartoons about the immense "Republican marches against hatred" which brought 4,000,000 people onto French streets at the weekend.
The centre-page spread of the magazine was a medley of cheeky cartoons about the immense "Republican marches against hatred" which brought 4 million people on to French strreets at the weekend.
The increase in the spread of antimicrobial resistance (AMR) in bacterial pathogens and limited availability of new antimicrobials places immense pressure on general practitioners (GPs) to prescribe appropriately.
Nineteen immense cranes spread across the landscape, with the foothills of Italy's Southern Alps in the background.
The shallow structural basin of the Kantō Plain, which stretches to the east of the Kantō Range, is the most extensive lowland of Japan; the immense metropolis of Tokyo spreads out from its centre, covering a vast area of the plain.
