Mechanistically, PDE5 inhibitors protect the heart against I/R injury through increased expression of nitric oxide synthases, activation of protein kinase G (PKG), PKG-dependent hydrogen sulfide generation, and phosphorylation of glycogen synthase kinase-3β — a master switch immediately proximal to mitochondrial permeability transition pore and the end effector of cardioprotection.
Thrombosis was caused immediately proximal to the stenosis by injection of a blood and thrombin mixture into a segment of the LAD which had intimal damage.
The plate was placed on the lateral cortex, and two drill holes immediately proximal to the osteotomy site were drilled and tapped.
The ROI was selected to be immediately proximal to the distal ends of both the MRI and CT models and extended proximally to the resection plane, though the resection plane was not included.
TOE can overcome most of these limitations, although there is a short segment of the distal ascending aorta immediately proximal to the right brachiocephalic artery that remains obscured due to the interposition of the right bronchus and trachea creating an acoustic mismatch.
Immediately proximal to the cap are the telomere associated satellite-like (TAS) sequences.
Touch was applied to the dorsum of the distal phalanx, immediately proximal to the fingernail.
In fact, intracellular Zn pools were associated with a distinct compartment immediately proximal to the ER (Figure 5, inset).
226 of these polymorphic gene models (40%) were perfectly correlated with individual SNPs, all of which were within or immediately proximal to the affected gene.
A fine, sterile iris scissors was then inserted immediately proximal to the forceps to make a single cut roughly perpendicular to the barbel shaft.
In the first step, separate ∼1 kbp genomic fragments immediately proximal to hupS and distal to hupL coding sequences were PCR amplified [13].
