Sentence examples for immediate replication from inspiring English sources
This interaction apparently had not been examined in the published literature before, but its immediate replication in a second cohort strengthened our confidence in this finding.
Yet, the discovery study in child psychiatry is rarely accompanied by an immediate replication effort.
Multiple imputations, immediate replication, models of causal inference, repeated measures and multiple informants are increasingly standard practice.
Large cohort studies offer ideal settings for discovery and replication efforts; they allow a large discovery sample and similar assessments are available for immediate replication.
The scientific rigor with multiple hypothesis testing and immediate replication must be adapted and applied before child psychiatrists embrace this new research opportunity.
This allows testing whether initial studies on a marker are more biased towards significant outcomes than late studies, or whether immediate replications tend to be biased against the result of the initial study.
Taken together, we propose that immediate-early replication origins contain specific sequence motifs that lead to their activation in the beginning of S phase, and that these origins ensure initiation of DNA synthesis regardless of their location in genome.
In NHOK, Bmi-1 knockdown did not elicit an immediate response of replication arrest and/or loss of viable cells, although the cellular replication rate was notably reduced and the senescence prematurely triggered.
Furthermore, Bmi-1 knockdown in HOK-16B-BaP-T cells, in which the p16INK4A/pRb pathway was abrogated, led to immediate arrest of replication and loss of viable cells.
This is substantiated by a recent paper by Bester et al. [ 50] showing an immediate induction of replication induced DNA damage upon HPV16E6E7 expression, whereas loss of heterozygosity and copy number variations only became evident after 100-250 population doublings.
As mentioned above, an immediate consequence of DNA replication (and consequently cell division) is the disruption of the existing chromatin structure by passage of the replication fork (Alabert & Groth, 2012; MacAlpine & Almouzni, 2013).
