Jeffrey R. Holmstead, the former head of the agency's office of air and radiation, said that a finding of endangerment from emissions of heat-trapping gases did not initiate immediate regulation but started a clock ticking on a process that typically took 18 months to two years.
But because immediate regulation of all such sources would result in overwhelming permitting burdens on permitting authorities and sources, EPA issued the Timing and Tailoring Rules, in which it determined that only the largest stationary sources would initially be subject to permitting requirements.
In a mere week, Senator Chuck Schumer called for immediate regulation and the blueprints themselves had been downloaded over 100,000 times.
We need immediate regulation that requires a convincing demostration that algorithms that are used to make impactful decisions about human lives are not unjust or unbiased or they are shut down.
The most interesting and specific responses were the immediate regulation of genes that might be involved in controlling the forward reactions of the two xanthophyll cycles in P. tricornutum.
These data indicate that some genes are poised for immediate regulation, others may represent downstream/indirect targets of ERα function, and still other gene targets may require the synthesis of cofactors to modify chromatin targets in preparation for the arrival of activated ERα [78].
Although our incubations with IMR-90 fibroblasts suggest that HMGCR alternative splicing is not regulated by non-sterol end-products of the mevalonate pathway, these results do not exclude the possibility of more immediate regulation (within 45 minutes post-treatment) of HMGCR alternative splicing by products other than cholesterol generated from the mevalonate pathway.
This ensured an immediate regulation over the metabolic flow across the endosymbiont's OM.
Thus, immediate regulation of cellular processes by ceramides and other sphingolipids may be mediated by salvaging pathways, whereas de novo synthesis of sphingolipids may modulate long-term cellular processes.
These studies demonstrate that, in spite of the highly polarised morphology of neurons, synaptic signals are rapidly conveyed to the nucleus to allow the immediate regulation of gene transcription.
Another possibility that must be considered is the dynamic and immediate regulation in miRNA levels in stress response (Marsit et al, 2006) and in hypoxia (Kulshreshtha et al, 2007); thus, time of collection and processing could impact miRNA levels.
