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Their first work was around dementia treatment, and the team showed that the tool could be used to correct protein imbalances in cells of dementia patients.
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As the control, the allele-specific PCR amplification was applied to genomic DNA, which caused equal amplification of ∗ 1 and ∗ 2. The allelic imbalance was evaluated in cells of culture cell lines, as well.
This herb medicine also improves redox imbalance in cells under the exposure of H2O2 as indicated by the attenuation in the reduction of activities of intracellular endogenous antioxidants, glutathione and glutathione peroxidase as well as catalase, and by the decrease in the leak of lactate dehydrogenase and the accumulation of malondialdehyde.
In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia.
Most of the observational data suggest that an oxidant/antioxidant imbalance exists in cells and lung tissue of patients with pulmonary fibrosis.
Some failures might be ascribed [ 95] to imbalances in Th cell subsets or the depletion of Breg cells.
The increasing availability of molecular biology tools has revealed the coexistence of numerous processes during carcinogenesis, from imbalances in the cell cycle to the development of a neoplastic tissue with invasive characteristics.
The pattern of genetic imbalances in these cell lines suggest that they represent good models for cervical carcinoma and HPV18 infection, providing another useful cellular model for the discovery and functional analysis of genomic alterations involved in cervical cancer when this viral type is present.
A line summary ideogram of the chromosomal imbalances in the cell lines is presented in Figure 1.
Moreover, a recent study found that imbalances in subsets of T cell populations might be responsible for the pathogenesis of AS, including increased ratios of Th1/Th2 and Th17/Treg cells [ 2].
In fact, cytosolic and mitochondrial redox imbalance was found in lymphoblastoid cells of ASD children compared to controls, an event exaggerated by exposure to thimerosal [ 92].
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