There is evidence that mitochondrial respiratory complex activity and mitochondrial membrane potential decline during aging and that endogenous antioxidant system activities exhibit an age-dependent decrease, making redox imbalance play a more predominant role in the aged cells and tissues.
Th1 Th2 imbalances play a pathogenic role in atopic disease in addition to autoimmune diseases such as multiple sclerosis.
Aside from the primary diseases, medications, mechanical ventilation and so on, ICU noise and light environment, and hormonal imbalance play essential roles [ 4- 8].
Surprisingly, however, there is very little evidence that mutations or chromosomal imbalances play a significant role in the loss of ER, suggesting that other regulatory or epigenetic mechanisms secondarily downregulate gene and/or protein expression.
For example, the formation and scavenging activity of free radicals in biological systems have been closely linked to a number of pathological conditions, and there is increasing evidence that ROS and the resulting prooxidant/antioxidant imbalance play a major role in AD [ 5, 6].
We hypothesized that ghrelin/obestatin imbalance played a role in the pathogenesis.
The neurovisceral integration model has proposed that autonomic imbalance plays an important role in the pathway from acute and chronic stress to cardiovascular disease.
For the primaries and caucuses, the imbalance played to his advantage, captured by the killer statistic of the season: His nearly $2 billion in free media was more than six times as much as that of his closest Republican rival.
Alas, Sino-American exchanges on international economic affairs are often heated: when America's treasury secretary, Hank Paulson, said recently that imbalances played a role in the run-up to the crisis, he provoked an outcry in China.
To determine whether luminance or contrast imbalances played a role in the onset biases observed in Carter and Cavanagh's [21] study, we explored the effect of minimizing the brightness and contrast differences between the two targets and across the visual field.
