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But given the highly imbalanced nature of the curated testing dataset (positive-to-negative ratio = 1 50), the false-positive rate must be properly controlled.
However, mining high-throughput screening (HTS) assay data remains a great challenge given the very large data volume and the highly imbalanced nature with only small number of active compounds compared to inactive compounds.
But, for now, the oil price is not the world's most pressing economic problem.That distinction goes to the imbalanced nature of the global economy.
These fortuitous conditions may not last, but for now they are good reasons not to be too pessimistic.High oil prices do, however, exacerbate the real weakness in the world economy: the imbalanced nature of global growth.
It is well known that datasets from HTS have the imbalanced nature, which means that the majority of screened compounds exhibit inactive outcomes, while just a minority part of them show active outcomes.
The experimental results reported in confusion matrices show that the LR + BS, DT + FS and SVM + SFFS are the best classification setups given the imbalanced nature of the patient dataset.
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This prior value is used to reflect the class imbalance nature of the gene function prediction problem, in which the number of negative genes is typically much larger than the number of positive genes.
Software quality datasets are, by their nature, imbalanced.
However, datasets in health domain are highly imbalanced, voluminous, conflicting and complex in nature, and these can lead to erroneous diagnosis of diseases.
Hence, deviations from perfect complementarity are expected to detect imbalanced probe/target interactions due to the asymmetric nature of the hybridization reaction on microarrays.
But the relationship is imbalanced.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com