It turns out, the imbalance changes a lot over time.
Heterogeneity was further demonstrated in the analysis of allelic imbalance changes along single exons from melanoma RNA-Seq.
In fact, on average, < 6.8% of the genome structure showed copy number alterations or allelic imbalance changes in primary tumor xenograft pairs.
What the authors then asked is, how does this imbalance change?
In addition, the imbalance ratio changes to analysis patterns.
As a result, it is unlikely that these imbalances affected changes occurring in the variables during the intervention period.
We hypothesize that some patients may show genomic imbalances and changes in the gene copy number that lead to genetic instability.
1998), which can have important consequences on growth and development (Raubenheimer and Jones 2006), although some organisms can compensate for nutrient imbalances through changes in feeding behavior (Raubenheimer and Simpson 1993; Morehouse and Rutowski 2010a; Jensen et al. 2011).
Dosage imbalance involves changes in protein concentrations relative to those of potential binding partners, potentially resulting in improper protein complex assembly (Veitia 2002), spurious interactions (Liberles et al. 2011), and deleterious downstream effects on pathways.
(Beats, four months old, has 200,000 subscribers to Spotify's 10 million, but that imbalance would change rapidly if Apple started pimping the app).
