This fact supports the authors Machado [ 24] when they state that the classifiers generated from imbalanced databases present high levels of false negatives for rare classes which is problematic when these are the classes being studied.
Upon unblinding of the TEMPO 3 4 database, an imbalance in hepatic injury, defined as alanine aminotransferase (ALT) >3 times the upper limit of normal (ULN), was observed for subjects receiving tolvaptan (4.4 %) relative to placebo (1.0 %).
This occurs because the database is imbalanced and the classifier therefore learns a lot about the negative class (majority) and little about the positive class (minority).
Participants in both groups will complete food records for 3 days (two weekdays and one weekend day) which will be analysed to assess for dietary deficiencies or imbalances, using a nutritional database software program (ESHA, http://www.esha.com), as well as gluten content.
Firth, H.V. et al. DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.
Firth HV, Richards SM, Bevan AP, Clayton S, Corpas M, Rajan D, et al. DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.
Lo FY, Chang JW, Chang IS, Chen YJ, Hsu SF, Tsai FY, et al. The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization.
Our array-CGH study provided an invaluable database of chromosomal imbalance regions and candidate genes in Asian and Caucasian lung cancer patients.
22 In addition, the fifth subtype of known pathogenic CNVs associated with ID was added as a positive control from Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources (DECIPHER) (http://decipher.sanger.ac.uk/).sanger.ac.uk/
Therefore, the method presented in this work would need to be extended to include other data, such as previous reports of comparable CNVs in databases such as DECIPHER (Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources) (Firth et al., 2009) and ISCA (Riggs et al., 2012), to be useful as a clinical differential diagnosis support tool.
