Since the maculopathy detected class (131 images) is imbalanced compared to the maculopathy not detected class (469 images), the maculopathy detected class was oversampled several times.
Red-shaded structures and bars indicate tissues with significant allelic-imbalance compared to control (***p < 0.001, **p < 0.01, *p < 0.05 by two-tailed t-test).
The BCL6− group had a higher frequency of genomic imbalances compared to the BCL6+ group.
Evidence from the literature suggests that funding allocation for AH research is low and imbalanced compared to that of other professions internationally [ 11, 15].
Thus, reducing base coverage had a proportionate effect on allelic imbalance identification compared to reduction in mapping to heterozygous sites.
Our results indicate that including any amount of genotype information, or both alleles at common variants, significantly increases accuracy of imbalance detection compared to predictions when complete genotypes are known.
The presence of aneuploid cells in most primary tumors examined in Gerlinger et al., is well documented by ploidy analysis (see supplementary Figure 10 in their paper) and metastases show a marked increase in allelic imbalance as compared to primary tumor regions.
Many retrospective studies, across a variety of sports, have found that athletes with a history of hamstring injury had significantly reduced thigh muscle strength and significant strength imbalance when compared to athletes with no history of hamstring injury [ 13, 15, 16].
