The available data suggest that clinical studies involving imaging of MDR function and in vivo modulation of MDR function can be performed with both tetrofosmin and MIBI, but the 2 should probably not be used interchangeably.
Attempts are being made to use MRI for imaging of renal function, including perfusion [ 1, 2], glomerular filtration rate [ 1, 3, 4] and intrarenal oxygen measurement [ 1, 5].
Quantitative imaging of liver function holds promise as an alternative to traditional measures of liver function, if properly validated.
However, the main production route with [F]F2 and commercially available stannyl precursors provides [F]F-DOPA in relatively low RCYs and SAs, limiting the use of this promising radiotracer to the imaging of neuronal function and brain malignancies, which is still its main application.
The majority of small animal PET systems use stationary detector gantries, thus affording high temporal resolution imaging of cardiac function.
Here we review the applicability of genetically encoded Ca2+ indicators for in vivo Ca2+ imaging of neural function.
2-Deoxy-2-18F-fluororibose (18F-2-DFR), which accumulates preferentially in the liver through the ribose salvage pathway, has been proposed for the imaging of liver function [30].
Diagnostic imaging of liver function includes positron emission tomography (PET) with [18F]fluorodeoxygalactose [19] 19] and dynamic contrast-enhanced magnetic resonance imaging [20] with gadoxetic acid [21] or gadoxetate disodium [22, 23].
Second, imaging of cardiac function and perfusion was performed followed by high-resolution contrast-enhanced MR angiography as specified in Table 3 for the standard MR imager and in Table 4 for the whole-body imaging system.
In the molecular imaging of kidney function with PET, the activity of glucose transporters (GLUT1, 3, and 4) has been expected to be assessed using 18F-FDG-PET even in the kidney.
