Exact(3)
Taken together, these results show high expression of the p53 reporter transgenic reporter in the regions requiring Shh for cell survival and the advantages of p53 reporter over in situ hybridizations for p53 target genes or antibody stainings against p53 [48] thanks to the possibility to do live imaging, label specific cell parts and change the fluorescent protein used for labeling.
Further, current radiotracers for Aβ imaging label predominantly fibrillar Aβ and do not measure soluble forms, providing only a partial quantification of Aβ burden.
A molecular imaging agent, defined as "a probe used to visualize, characterize, and measure biological processes in living systems" (Mankoff 2007), is typically composed of an imaging label, a carrier that contains (a) targeting ligand(s) or is a targeting ligand, and a linker between the carrier and the label.
Similar(57)
Exquisite control of each of these parameters is required for their use as biological imaging labels and components in a variety of device architectures for photovoltaics and image sensors.
With their rapid progress, various QDs-bioconjugates have been developed for imaging, labeling, and sensing [15].
Using QDs as drug models and imaging labels to evaluate nano-particle formulations incorporating both hydrophilic and hydrophobic drugs and imaging agents is developed.
Nanoparticle (NP) engineering, an alternative to genetic engineering, is similarly able to incorporate imaging labels on cells at a high efficiency while being less detrimental to the cell.
Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoparticle to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers.
In this chapter, we have divided the imaging agent preparation techniques into two main categories: integrating additional imaging labels into existing nano-vehicle via either surface modification, or function loading and synthesis of NMs with multimodal endogenous contrast.
In this work, we describe dual-modality nanoparticle drug conjugates (NDCs) which utilize protease sensitive linkers to attached drug compounds and imaging labels to a clinically translated class of ultrasmall silica nanoparticle (C′ dots).
With the easily modifiable surface chemistry of nanoparticles, two or even more imaging labels can be introduced to a single nanoparticle with multiple linking agents (ligands) or direct-incorporation.
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