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Well-designed, prospective studies with 12 36 months of clinical follow-up after ioflupane (I) imaging, in which blinded image evaluation by 3 5 independent nuclear medicine physicians (no access to clinical information) was used for image assessment.
Following NP exposure, cells were imaged using darkfield hyperspectral (HS) imaging, in which complete optical scattering spectra can be obtained at each pixel location within the images.
Figure 7 gives three examples of such imaging in which the negative bias image shows non-periodic surface features that are not evident in the positive bias scan of the same area.
Among the former one finds reflectance imaging [ 8, 9, 11] and OCT [ 4– 6, 14– 16], while the latter includes dual-imaging modalities, such as fluorescence imaging, in which one of the retinal layers being imaged is used as a registration signal to compensate for eye motion in a second imaging channel [ 10, 12].
Four reaction wheels are also used for precise attitude control during activities requiring a highly stable platform, such as high-resolution imaging, in which even small motions can cause blurring of the image.
We examined individual cell motility by live-cell imaging, in which we followed live cells for 14 hours, acquiring phase contrast images every 15 min (Figure 3 and Movies S1, S2, S3).
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Near-infrared (NIR) hyperspectral imaging is an imaging technique in which spectral and spatial information are combined to obtain NIR hyperspectral images [ 16– 16].
Photoacoustic (PA) imaging is an imaging technique in which tissue is irradiated with nanosecond pulses of low-energy laser light [ 11].
FLAIR imaging represents a T2-weighted imaging protocol in which the signal from the cerebrospinal fluid is suppressed.
Photoacoustic imaging (PA) is a noninvasive biomedical imaging modality in which laser generated ultrasound waves are used to obtain 3D images of soft tissue [ 1].
If detailed anatomical information is also needed, a second imaging technique or a multi-modality imaging approach in which the optical scanner is combined with another modality (e.g. MRI, ultrasound) could offer a solution.
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