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Migraine is not as benign a disease as it was thought before the imaging era since migraine is an independent risk factor for deep white matter lesions, silent posterior circulation territory infarcts, and infratentorial hyperintense lesions [1 4].
In a modern metabolic imaging era, F-FDG PET is useful when differential diagnosis of brain tumors is difficult, and PCNSL is considered as one of the differential diagnoses, but F-FDG PET is not a perfect tool, and early tumor biopsy is still necessary especially with atypical radiological findings.
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The merit of his approach was the aim to bridge the gap between these 2 fields in a pre-imaging era.
23 This grading system, incorporating both clinical descriptors and a theoretical pathological correlation, provides the most detailed grading of the pre-imaging era (see online supplementary table 1 for details).
In this genomic era, imaging the working products of the genome inside a living cell, in a model organism of human disease (e.g. mouse models) and in human patients is one of the most powerful approaches to advance our knowledge.
Lastly, much of the early single-agent cytotoxic chemotherapy literature occurred before the current magnetic resonance imaging (MRI) era became widespread.
The annular bright-field image, a phase-contrast image first proposed by Rose, Rosee 1974) has also become popular in the aberration-corrected era for imaging light atoms (Findlay et al. 2010; Ishikawa et al. 2011).
Only in systematic development pathways this goal can be reached and imaging can come to another era beyond the image.
21 Because of a low predictive value to indicate the site of lesion, in the era of modern imaging the stapedius reflex slipped out of focus.
Manson was also a daring and accurate surgeon who tried to tackle liver abscess which was almost invariably fatal in his era with no organ imaging facilities and antibiotics.
We expect that these cases will contribute to the further characterization of the CMV retinitis manifestation in the era of HAART and OCT imaging.
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