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Many of the approaches to image stem cells are promising but further work is required before a wide clinical translation becomes reality.
While a number of studies have used the HSV-tk system to tag stem cells for myocardial infarction [ 50, 51], only several studies to date have used the HSV-tk system to image stem cells intracranially.
doi: 10.7554/eLife.07918 Image Stem cells with TERT promoter mutations can still differentiate into more specialized cells such as nerve cells Most cells in the human body have a limited lifespan.
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Currently, we have 365 images for differentiated cells and 36 images for stem cells registered in the database.
In order to be visible on PET and MR images, the stem cells are labeled with a PET tracer and an MRI contrast reagent, respectively, prior to cell transplantation.
Figure S1: Fluorescence image of DF stem cells induced to differentiate into neuronal cells.
b Scanning electron microscopy image of neural stem cells (orange) grown on SiNP films (blue).
Dual or triple fusion reporter proteins have been developed to image cancer or stem cells and employed Renilla luciferase or firefly luciferase (Photinus pyralis) fused to green fluorescent proteins (GFPs) or red fluorescent proteins (RFPs) [ 6– 8].
Figure 4 Time course phase contrast images of mesenchymal stem cells (MSCs).
Comparing images of embryonic stem cells made with AFM and SICM, he found that the SICM images revealed things that had been invisible under AFM.
After the landmark fraud case involving manipulated images and stem cell scientist Woo Suk Hwang broke at Science, journal editors began traveling to Rossner's New York office to learn how to study images and detect problems, and he often spoke out and wrote about the issue.
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