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Clusters 13 and 14 (Figure 6C) illustrated genes with a small increase in gene expression and a rapid recovery in SAPSII-low group of patients and a high increase over time in SAPSII-high patients.
Cluster 8 and 9 illustrated genes which were up-or down regulated during the whole period of differentiation.
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The upper panel illustrated gene editing strategy on KAT5.
The OPEN Zinc Finger Nuclease Sites track shows that within the 2.187 kb region illustrated (gene YLR219W) there are 17 potential ZFN target sites located in the coding region of this gene.
A recent report has illustrated gene expression changes induced by coculture of AGS cells with H. pylori and attempted to correlate these expression changes with known cytogenetic anormalities in gastric cancer (Myllykangas et al, 2004).
(B) A cluster illustrating genes that are downmodulated in patients versus controls, with genes remaining downmodulated over time in SAPSII-high group only.
(C) A cluster illustrating genes that are upmodulated in patients versus controls, with genes remaining upmodulated over time in SAPSII-high group only.
Figure 4 illustrates genes which were annotated based on domain, motif, family and fold searches.
By contrast, centroids 8 and 12 in Figure 3A illustrate genes that show relatively small changes in expression, except at the 48 hour neomycin time point where they were all up regulated.
Figure 6D illustrates genes of interest for which expression was modified in our experiments (Lopaschuk et al. 2010).
The ratios of RPKM values (mutant to wild type) were log-transformed to better illustrate genes that were differentially expressed in parS and parR mutants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com