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Our findings illustrate that activation of HH signaling, even with an acute postnatal stimulation, can lead to localized dysmorphology of the skull by generating modular shape changes in the facial skeleton.
Similar(59)
This observation is particularly important because it illustrates that activation of mTOR could be a viable target for therapies that are aimed at preventing disuse atrophy.
This novel discovery represents the principal finding of the present study, which, for the first time, illustrates that activation of c-Jun is differently regulated in SCs compared to in DRG sensory neurons.
In other words, our results clearly illustrate that the activation of mTOR signaling should be considered as a viable target for therapies that are aimed at preserving muscle mass during periods of mechanical unloading.
In earlier studies, we have illustrated that constitutive activation of the Hh signaling pathway in chondrosarcoma is rarely caused by PTCH1 or SMO mutations, and therefore the aberrant activation of the pathway in chondrosarcoma is more likely due to downstream molecules, such as GLI proteins, which act as very important nuclear executors and mediate Hh signaling at the distal end of the pathway.
Studies of the retinotectal system have illustrated that BDNF, through activation of the TrkB, promotes branching of retinal axons [ 38, 39].
These studies illustrate that substrate-induced catalytic activation of pol β provides an optimal enzyme conformation even in the presence of a strongly destabilizing point mutation.
These results illustrate that the apoptosis of SMMC-7721 cells induced by LK-A is mediated by the activation of the ROS/JNK/c-Jun pathway.
The ability of independent selective voluntary activation of regions within the trapezius muscle with biofeedback guidance [ 41] illustrates that differential activation between regions of the upper trapezius may be a voluntary neuromuscular strategy.
It has been illustrated that BRAT1 regulates activation of ATM and DNA-PK under conditions of DNA damaging stress.
This illustrates that reading activation is determined by the interaction of cognitive abilities and learning environment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com