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Depression is the predominant and prevailing symptomatic illness phase.
Individuals with BD present with deficits for both domains, across illness phase, i.e., in manic, depressed, or euthymic states (Samamé 2013).
Early mobilization referring to initiating physical exercise or mobilization within the early illness phase is an increasingly common practice in intensive care units (ICU) [1].
It is unclear whether these patterns are indicative of a continuously active pathological process, residual effects of an earlier illness phase or pre-illness onset developmental risk factors.
A source of confusion has been that some researchers have failed to consider that prodromal symptoms should be continuous with the acute illness phase of the disorder.
Thus, patients in our sample are more impulsive than population norms, pointing towards the consideration of impulsivity as a trait characteristic of bipolar disorder, independent of current illness phase.
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These are potentially important, as acute changes in medication regime, reduced levels of adherence, or different treatment protocols for different illness phases could affect activity in our sample.
The main objective was to identify the degree and pattern of cognitive deficits present in FEM by systematically reviewing the literature focusing on two illness phases: cognitive functioning during the first acute manic state and in the following remission period.
First, the interpretation of the findings in the context of diagnostic criteria for BD and research on activity in different illness phases; second, consideration of the limitations of the study; and third, the implications of the methodology for the role of actigraphy and BD.
Furthermore, the course of these cognitive deficits during the different illness phases is not entirely clear.
Finally, dates of illness phases were not exact as we relied on retrospective report of illness attributions and service encounters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com