Sentence examples for illegitimate expression of from inspiring English sources

Cytospins were also double stained with anti-CD45 (common leukocyte antigen) antibody to exclude possible illegitimate expression of cytokeratins on hematopoietic cells.

These false positives stem from multiple sources, including issues with laboratory technique, primer selection, and illegitimate expression of the target genes in leukocytes.

The numerous false-positive findings in our assay and the reported presence of p503S, p504S and p510S in normal hematopoietic tissues also from patients without prostate malignancies [ 20], could depend on illegitimate expression of gene transcripts.

A recently published review concluded that Tg mRNA measurement is an invalid approach in the postoperative care of patients with DTC due to illegitimate expression of this marker in peripheral blood cells, although RT PCR concepts in general are worthy of further investigations (Verburg et al, 2004).

More recently, methods for the positive or negative enrichment of tumour cells, prior to detection using PCR and RT-PCR assays, have reduced the rate of false positivity from illegitimate expression of some more commonly used markers in normal blood cells [ 33- 35].

But despite briefs urging them to regard the state provisions as the illegitimate expressions of religious bias, the justices expressed little interest in the past and great concern about the future.

However, as immunomagnetic cell isolates have very low contamination by PBLs, it is desirable to check the possibility of illegitimate expression in the very low number of PBLs that are retained after an immunobead harvest.

One possible explanation of the maternal contribution to these apparently "placenta-derived" transcripts in whole blood may be related to the phenomenon of illegitimate expression that lymphocytes had been shown to express transcripts irrelevant to their functions [26] [28].

Using more than a single marker gene, as applied in our experiments, is a potential way to overcome the problem of illegitimate expression (Chelly et al, 1989), assuming that there is a little chance of encountering significant illegitimate mRNA of more than one gene at a time.

It is nevertheless important to assess whether this small number of cells can lead to false positives due to illegitimate expression.

Illegitimate expression by maternal blood cells would need to be excluded before adopting such a marker.