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On the basis of activity and safety profile, we conducted the current phase II study to explore the efficacy of ziv-aflibercept in the first-line setting.
Based on these results, we planned a phase II study to explore safety and efficacy of a weekly FU/FA/oxaliplatin regimen in elderly (> 70 years old) advanced gastric cancer patients.
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A phase II study in breast cancer was originally designed as a randomized 3-arm study to explore 2 distinct dosing regimens of cabazitaxel and to further assess the activity of the novel taxane larotaxel.
For example, Qin et al. developed a two-stage MGWA study to explore relationships between gut microbiome and type II diabetes [ 2, 10].
A potential approach to this is to combine active agents, and given that sorafenib and infliximab have different mechanisms of action and have non-overlapping toxicity profiles, we carried out a phase I/II study to explore the safety and efficacy of this combination at the full single agent doses of both drugs.
The aim of the present multicenter open-label Phase II study was to explore the efficacy and safety of biweekly administration of cetuximab and mFOLFOX-6 or XELOX as first-line chemotherapy in patients with metastatic colorectal cancer.
We report here the final results of a multicentre, open label phase II study designed to explore the efficacy of the combination of pemetrexed and carboplatin with bevacizumab as front-line therapy in patients with unresectable MPM.
The produced biochar was further subjected to mono-element sorption studies to explore the effect of the pH value of the sorbate solution on the removal efficiency of Cu II), Cd II) and Pb II) ions.
It needs further studies to explore.
A Phase II study was conducted to explore the safety and efficacy of biweekly administration of cetuximab combined with mFOLFOX-6 or biweekly XELOX in patients with KRAS codon 12, 13, 61 wild-type and BRAF (V600E) wild-type mCRC.
The RESPOND Research Evaluating Serial Protein CC levels in severe sepsis patients ON Drotrecogin alfa [activated]) trial is a phase II study being conducted to explore the use of endogenous protein C level as both a biomarker and a steering parameter for administration of DrotAA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com