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Patients in the latter study were significantly more likely to develop distant recurrence if they presented with a tumour IFP value above the group median (19 mmHg), which suggests a role for IFP in metastatic spread.
These data, coupled with the breadth of data demonstrating elevated IFP in a wide range of human tumours [ 7, 18, 19, 21- 25], designate high tumour IFP as an important therapeutic problem.
Cervical cancer patients with primary tumors with high IFP have a poor prognosis and may benefit from aggressive treatment, implying that a noninvasive method for assessing IFP in cervical carcinomas is needed [ 8- 10].
Results: phenylephrine given i.v. increased the systemic blood pressure, and significantly decreased the IFP in the LO phase (78% of pre-treatment value).
Local administration of l-NAME (1 ml of 2 μM) significantly lowered (P<0.05) the IFP in the MO and LO phases, but was without effect in the PO phase.
After successfully defending his thesis in 2015, Balsa-Barreiro has been working on various research lines and projects, In mid-2015 he took up the position as EU experienced researcher at the Institute for Photogrammetry (IFP) in Stuttgart, funded by the fellowship program of Marie Curie.
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No significant differences were seen at any time point in IFP measured in the tumours receiving either hyperthermia treatment when compared with untreated tumours.
Toghraie et al. demonstrated that ADSCs derived from IFPs in rabbits given to rabbits with OA-induced knees had less cartilage destruction, less subchondral sclerosis, less osteophyte buildup, as well as better cartilage overall than the control group [43].
This vector was generated by amplification of 6xHis-IFP in a two-step PCR reaction.
In contrast, IFPs in autochthonous PDAs were dramatically elevated, ranging from 75 to as high as 130 mm Hg, rivalling mean arterial pressures (Provenzano et al, 2012).
The reduction in IFP correspondingly resulted in a dramatic increase in patent tumour vessels without affecting overall vessel number, and ready penetration of chemotherapies across the tumour bed.
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