Ultrasound probe could not break completely the nanoparticle clusters found in powder form to the primary diameter of 12 nm even if sonication time was extended.
Digitoxin was the most potent of the CGs tested, and the measured IC50 value was comparable with therapeutic serum concentrations, especially if exposure time was extended to 6 days.
The simulation time was limited to January 2072 due to the length of time it would take and large computational cost if the predicted time was extended.
A tiny whitish suspension was sometimes observed if the reaction time was extended or a high concentration of ammonia was used.
Since the efficacy could not be improved by simply increasing the dose, we asked whether the efficacy may change if the dosing time was extended.
However, if the annealing time was extended to 60 min, the mass migration and SiGe intermixing effects resulted in the appearance of super domes, as shown in Figure 7b.
In preliminary experiments, we discovered that M7-DLO, unlike M5-DLO, was not detectably flipped in proteoliposomes that were incubated on ice, even if the incubation time was extended to 60 min. However, when proteoliposomes were incubated at 25 °C for >30 min, the percent of [H]M7-DLO captured by Con A was identical to that seen for [H]M5-DLO.
If single intravenous administration time was extended to 3 hours, the serum concentrations of drugs were able to meet the PK/PD standard (T> MIC%> 50%) for treating common, highly resistant bacteria.
The results of the present research consistently suggested that, if cefoperazone/sulbactam single infusion time was extended to 3 hours, the serum drug concentration achieved the PK/PD standard of T>MIC% greater than 50% (MIC9064 mg/L).
Exercise time was extended once more.
No further improvement is seen if this time is extended (Ishikawa-Takata et al 2003).
