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We can thereby reject the null hypothesis even if the attributable fraction to LS is small.
There is evidence of biological interaction if the attributable proportion is not equal to 0. The present cohort had >80% power to detect the published OR of 1.13 at the 5% significance level (α=0.05) with a risk allele frequency of 0.42.
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However, the candidaemia rate in the placebo arm of this meta-analysis is 4.5% and the expected absolute risk reduction in hospital mortality is about 2.25% if we assume that the attributable mortality of candidaemia is 50% [ 7].
While some studies have suggested a link between occupational exposure to benzene and increased risk of AML, others have suggested the attributable risk, if any, is slight.
This approximation is likely to produce some bias, which is expected as an underestimation of the attributable number if compared to the backward version.
The proportion of CVD that would be prevented in the MS-positive population if the MS were prevented (the attributable proportion in the exposed, APe), and the proportion of CVD that would correspondingly be prevented in the total population (the attributable proportion in the total population, APt) are 33% and 10% respectively.
If the trial showed that VAP was reduced to 10% in the intervention arm (a 50% reduction), and if it was assumed that the attributable mortality due to VAP is about 10%, then at very best mortality could only be reduced by a statistically non-significant (but clinically important) four patients.
If there is no interaction, the Attributable Proportion will equal 0. To adjust for potential confounding from covariates, we used the propensity score method to obtain adjusted estimates of the measures of association and interaction between neighborhood/housing conditions with presence of diabetes on incident lower-body functional limitations [ 23, 24].
For each exposure, we calculated the relative risk (RR) of becoming a case using the chi-square test and the attributable fraction (AF, only if RR > 1).
Regional variation in iF is attributable to urban form and meteorology (Table 2).
This reproducible positioning also ensures that the minimal sensitivity of the Swisstrace probe (Swisstrace, Zurich, Switzerland) to Cerenkov radiation [31] is also unlikely to be of consequence to the accuracy of the measured IF, as the number of counts attributable to Cerenkov radiation was concluded to be related to the depth of the scintillating fiber in the volume of activity.
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